Michalis Averof

Michalis Averof
Résidents Labex RFIEA+
pas Eurias

dates de séjour

17/09/2012 - 30/06/2013



Fonction d’origine

Directeur de recherche

Institution d’origine

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas (Grèce)

Fonction actuelle

Directeur de recherche

Institution actuelle

CNRS, Institut de Génomique Fonctionnelle de Lyon (France)

pays d'origine


projet de recherche

Does regeneration reset the age clock ? Assessing senescence in regenerated organs.

Cells in an ageing organism gradually lose the ability to perform important cellular functions and to respond to stress. Certain privileged populations of cells, such as germ cells, are able to escape ageing. It is uncertain if other types of cells that contribute to tissue renewal, such as stem cells, are similarly protected from ageing.
Many animals have the ability to regenerate body parts that are lost through injury. Regeneration restores both the number of cells and the diversity of cell types of the lost tissue, by mobilizing specific populations of progenitor cells. It also restores pattern, giving rise to well-proportioned and functional organs that are virtually indistinguishable from those of unharmed animals. This project explores whether regeneration can restore the consequences of ageing and how one could assess that experimentally.
We are establishing genetic tools to study limb regeneration in a small crustacean, named Parhyale hawaiensis. Adult Parhyale can completely regenerate their limbs within a week. We recently identified a number of genes that are differentially expressed in young versus aged Parhyale limbs. These genes will serve as markers to assess whether regenerated limbs exhibit the same degree of senescence as their non-regenerated counterparts.


Since 1999 Michalis Averof has been a researcher and group leader at the Institute of Molecular Biology and Biotechnology (IMBB) in Crete. He was recently appointed group leader at the Institut de Génomique Fonctionnelle de Lyon (IGFL) and will establish his research team in Lyon. He obtained a Biology degree at Trinity College, Dublin, a PhD at the University of Cambridge, and carried our post-doctoral research at the European Molecular Biology Laboratory (EMBL) in Heidelberg. His research lies at the interface of developmental and evolutionary biology: it compares developmental mechanisms among different animals to explore how their bodies are built and how morphological diversity arises during evolution.


Michalis Averof a été lauréat d'une bourse ERC en 2015 pour son projet "Unraveling complex organ regeneration through live imaging and molecular profiling approaches".


Michalis Averof a été recruté comme DR2 par le CNRS et travaille à l'IGFL (Institut de Génomique Fonctionnelle de Lyon).


17/06/2013 - 10:30 - 12:30